DNA - Templated Aldol Reaction

Hi all,
A recent paper (Angew. Chem. Int. Ed. 2007, 46, 7297-7300.) which i found intersting was based on DNA- templated reactions. There are only two reports on DNA - templated reactions thus far.

In this paper a Proline tethered to a DNA strand can efficiently catalyzed the cross aldol reaction of a complementary DNA - Aldehyde conjugate with a non - tethered ketone. The intresting aspect was the catalytic turnover achieved first time in a DNA templated reaction.

Good paper to read on.

Ahamed.